Since the call for a shift to evidence-based practice began in the early 1990s, there has been an increasing reliance on finding and using the results of well-conducted research to inform practice. However, the number of reports of primary research is too high and the skills and resources needed to find, screen and read the 'best' evidence eludes most practitioners. This has led to the growth in production and release of evidence-based clinical practice guidelines, and the foundation for the evidence—systematic reviews. The genesis of The Cochrane Collaboration in 1993 set the stage for the development of a worldwide infrastructure to support the production, publication and maintenance of systematic reviews to inform healthcare decision-making.